Health IT & Interoperability

IISImmunization Information System

A confidential, population-based state registry that records immunization doses administered within its jurisdiction.

Reviewed June 2026 by Enterprise Health

Key facts

  • A confidential, population-based state vaccine registry.
  • Consolidates doses so providers see a complete history.
  • Bidirectional HL7 exchange keeps records authoritative.

What it means

An IIS — a state or regional immunization registry — consolidates vaccination records so providers can see a complete history and avoid duplicate doses. Bidirectional HL7 exchange lets an employee- or student-health system query and report doses, keeping immunization tracking authoritative and reducing the records-chasing that plagues onboarding.

Frequently asked

What is an IIS?

An Immunization Information System — a state or regional registry that records vaccine doses administered in its jurisdiction, giving providers a consolidated immunization history and avoiding duplicate doses.

How does a health system use an IIS?

Through bidirectional HL7 exchange, an employee- or student-health system queries and reports doses to the IIS, keeping immunization tracking authoritative and cutting onboarding records-chasing.

A certified, interoperable system of record.

See how Enterprise Health exchanges data using HL7, FHIR and the standards your stack already speaks.